Issue 97, 2018
From the journal:

Chemical Communications

The other side of the superoxide radical anion: its ability to chemically repair DNA oxidized sites†

Leonardo Muñoz-Rugeles, ORCID logo *a   Annia Galano ORCID logo b  and  Juan Raúl Alvarez-Idaboy ORCID logo *a  

* Corresponding authors

a Facultad de Química, Departamento de Física y Química Teórica, Universidad Nacional Autónoma de México, Mexico City, Mexico
E-mail: leomunozr@comunidad.unam.mx, jidaboy@unam.mx

b Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina. Iztapalapa, Mexico City, Mexico

Abstract

The superoxide radical anion can repair oxidative damage. In particular, it was demonstrated that O2˙− can repair oxidized DNA by electron transfer, restoring the original structure of this important molecule. Acid–base equilibria have been considered, and the influence of the pH on the main reaction mechanism has been explored.

Graphical abstract: The other side of the superoxide radical anion: its ability to chemically repair DNA oxidized sites

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Article information

DOI
https://doi.org/10.1039/C8CC07834C
Article type
Communication
Submitted
30 Sep 2018
Accepted
12 Nov 2018
First published
12 Nov 2018

Chem. Commun., 2018,54, 13710-13713

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The other side of the superoxide radical anion: its ability to chemically repair DNA oxidized sites

L. Muñoz-Rugeles, A. Galano and J. R. Alvarez-Idaboy, Chem. Commun., 2018, 54, 13710 DOI: 10.1039/C8CC07834C

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