We report site-specific triple click labeling for DNA and RNA in a one-pot setup by performing inverse electron demand Diels–Alder reaction and strain-promoted and copper catalyzed click reactions sequentially. Our methodology can be applied to long and short nucleic acids alike, and could have broader potential for labeling other (bio-)molecules.
M. Winz, E. C. Linder, J. Becker and A. Jäschke, Chem. Commun., 2018, 54, 11781 DOI: 10.1039/C8CC04520H
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