Here, we developed two pairs of high-contrast chemical probes and their RNA aptamers with distinct readout channels that permitted simultaneous live-cell imaging of endogenous β-actin and cortactin mRNAs. Application of this technology allowed the direct observation of the formation process of stress granules, protein–RNA assemblies essential for cellular response to the environment.
K. Yatsuzuka, S. Sato, K. B. Pe, Y. Katsuda, I. Takashima, M. Watanabe and M. Uesugi, Chem. Commun., 2018, 54, 7151 DOI: 10.1039/C8CC03805H
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