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A rapid synthesis of the C1–C13 fragment of biselynbyolide A and B is reported. The judicious use of catalytic transformations for C–C bond formation and stereocenter generation greatly minimizes the use of protecting groups and oxidation state changes, as compared to previously reported routes to similar fragments.

Graphical abstract: Rapid, enantioselective synthesis of the C1–C13 fragment of biselyngbyolide B

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