Issue 10, 2010

Efficient, direct α-methylenation of carbonyls mediated by diisopropylammonium trifluoroacetate

Abstract

A very efficient method for the direct α-methylenation of carbonyl compounds, with yields up to 99%, utilizing paraformaldehyde, diisopropylammonium trifluoroacetate, and catalytic acid or base, is presented.

Graphical abstract: Efficient, direct α-methylenation of carbonyls mediated by diisopropylammonium trifluoroacetate

Supplementary files

Additions and corrections

Article information

Article type
Communication
Submitted
23 Nov 2009
Accepted
07 Jan 2010
First published
25 Jan 2010

Chem. Commun., 2010,46, 1715-1717

Efficient, direct α-methylenation of carbonyls mediated by diisopropylammonium trifluoroacetate

A. Bugarin, K. D. Jones and B. T. Connell, Chem. Commun., 2010, 46, 1715 DOI: 10.1039/B924577D

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