Correction: Photocrosslinkable, biodegradable hydrogels with controlled cell adhesivity for prolonged siRNA delivery to hMSCs to enhance their osteogenic differentiation

Abstract

Correction for ‘Photocrosslinkable, biodegradable hydrogels with controlled cell adhesivity for prolonged siRNA delivery to hMSCs to enhance their osteogenic differentiation’ by Minh Khanh Nguyen et al., J. Mater. Chem. B, 2017, 5, 485–495.

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The authors regret the following errors in the original manuscript.

1. Old text in “Hydrogel preparation” section:

The hydrogels were formed upon exposure of DEX-MAES solutions to 320–500 nm UV light at 2.5 mW cm⁻² for 2 min using an Omnicure S1000 UV Spot Cure System (Lumen Dynamics Group, Mississauga, Ontario, Canada).

Correction (bold text was changed and/or added):

The hydrogels were formed upon exposure of DEX-MAES solutions to 320–500 nm UV light at ∼20 mW cm⁻² for 2 min using an Omnicure S1000 UV Spot Cure System (Lumen Dynamics Group, Mississauga, Ontario, Canada). Note: UV intensity was measured as 2.5 mW cm⁻² during the performance of this study using a UV meter that was later determined to be malfunctioning and supplying erroneous values. Once this was discovered, the UV intensity was remeasured to be ∼20 mW cm⁻² based on the original instrument experimental setup parameters using a new and properly functioning UV meter. Although there may have been slight changes within the Omnicure UV instrument over time such as decreased bulb output, the updated UV intensity of ∼20 mW cm⁻² more accurately represents that actually used and replaces the previously reported value throughout this paper.

2. Old text in “Rheology” section:

PBS solutions of DEX-MAES containing 0.05% w/v Igracure D-2959 photoinitiator were placed between a glass plate and a quartz plate separated by two 0.75 mm spacers followed by photocrosslinking via the application of UV light (2.5 mW cm⁻²) for 2 min.

Correction (bold text was changed):

PBS solutions of DEX-MAES containing 0.05% w/v Igracure D-2959 photoinitiator were placed between a glass plate and a quartz plate separated by two 0.75 mm spacers followed by photocrosslinking via the application of UV light (∼20 mW cm⁻²) for 2 min.

3. Old text in “Viability and osteogenic differentiation of encapsulated hMSCs in hydrogels” section:

The hydrogels were cultured in 24 well plates with 0.5 ml of osteogenic media (10 mM β-glycerophosphate (CalBiochem, Billerica, MA), 50 μM ascorbic acid (Wako USA, Richmond, VA), 100 nM dexamethasone (MP Biomedicals, Solon, OH) and 100 ng ml⁻¹ BMP-2 (Department of Developmental Biology, University of Würzburg, Germany)).

Correction (bold text was added):

The hydrogels were cultured in 24 well plates with 0.5 ml of osteogenic media (DMEM-LG supplemented with 10% FBS, 1% penicillin/streptomycin (Fisher Scientific), 10 mM β-glycerophosphate (CalBiochem, Billerica, MA), 50 μM ascorbic acid (Wako USA, Richmond, VA), 100 nM dexamethasone (MP Biomedicals, Solon, OH) and 100 ng ml⁻¹ BMP-2 (Department of Developmental Biology, University of Würzburg, Germany)).

4. Fig. 6C in the original manuscript is a mistaken duplicate of Fig. 6A. The correct version of Fig. 6C is shown below:

The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.

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