Total synthesis of levetiracetam, an active ingredient of epilepsy treatment medications, is reported. The reported method is based on a one-pot dehydration/sigmatropic rearrangement of (R,E)-hept-4-en-3-ol carbamate to the corresponding allylamine derivative, an advanced precursor of levetiracetam.
A. Narczyk, M. Mrozowicz and S. Stecko, Org. Biomol. Chem., 2019, 17, 2770 DOI: 10.1039/C9OB00111E
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