Issue 10, 2018

Multicomponent self-assembly as a tool to harness new properties from peptides and proteins in material design

Abstract

Nature is enriched with a wide variety of complex, synergistic, and highly functional protein-based multicomponent assemblies. As such, nature has served as a source of inspiration for using multicomponent self-assembly as a platform to create highly ordered, complex, and dynamic protein and peptide-based nanostructures. Such an assembly system relies on the initial interaction of distinct individual building blocks leading to the formation of a complex that subsequently assembles into supramolecular architectures. This approach not only serves as a powerful platform for gaining insight into how proteins co-assemble in nature but also offers huge opportunities to harness new properties not inherent in the individual building blocks. In the past decades, various multicomponent self-assembly strategies have been used to extract synergistic properties from proteins and peptides. This review highlights the updates in the field of multicomponent self-assembly of proteins and peptides and summarizes various strategies, including covalent conjugation, ligand–receptor interactions, templated/directed assembly and non-specific co-assembly, for driving the self-assembly of multiple proteins and peptide-based building blocks into functional materials. In particular, we focus on peptide- or protein-containing multicomponent systems that, upon self-assembly, enable the emergence of new properties or phenomena. The ultimate goal of this review is to highlight the importance of multicomponent self-assembly in protein and peptide engineering, and to advocate its growth in the fields of materials science and nanotechnology.

Graphical abstract: Multicomponent self-assembly as a tool to harness new properties from peptides and proteins in material design

Article information

Article type
Review Article
Submitted
09 Feb 2018
First published
26 Apr 2018

Chem. Soc. Rev., 2018,47, 3721-3736

Multicomponent self-assembly as a tool to harness new properties from peptides and proteins in material design

B. O. Okesola and A. Mata, Chem. Soc. Rev., 2018, 47, 3721 DOI: 10.1039/C8CS00121A

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