Alejandro
Méndez-Ardoy
a,
Nagula
Markandeya
b,
Xuesong
Li
b,
Yu-Tang
Tsai
a,
Gilles
Pecastaings
c,
Thierry
Buffeteau
a,
Victor
Maurizot
b,
Luca
Muccioli
a,
Frédéric
Castet
a,
Ivan
Huc
*b and
Dario M.
Bassani
*a
aUniv. Bordeaux CNRS UMR 5255 ISM, 351, Cours de la Libération, 33405 Talence, France. E-mail: dario.bassani@u-bordeaux.fr
bUniv. Bordeaux CNRS UMR 5248 CBMN, 2 rue Escarpit, 33600 Pessac, France. E-mail: i.huc@iecb.u-bordeaux.fr
cInst. Polytechnique de Bordeaux CNRS UMR 5629 LCPO, 16, Av. Pey-Berland, 33600 Pessac, France
First published on 13th September 2017
Aromatic foldamers are bioinspired architectures whose potential use in materials remains largely unexplored. Here we report our investigation of vertical and horizontal charge transport over long distances in helical oligo-quinolinecarboxamide foldamers organized as single monolayers on Au or SiO2. Conductive atomic force microscopy showed that vertical conductivity is efficient and that it displays a low attenuation with foldamer length (0.06 Å−1). In contrast, horizontal charge transport is found to be negligible, demonstrating the strong anisotropy of foldamer monolayers. Kinetic Monte Carlo calculations were used to probe the mechanism of charge transport in these helical molecules and revealed the presence of intramolecular through-space charge transfer integrals approaching those found in pentacene and rubrene crystals, in line with experimental results. Kinetic Monte Carlo simulations of charge hopping along the foldamer chain evidence the strong contribution of multiple 1D and 3D pathways in these architectures and their dependence on conformational order. These findings show that helical foldamer architectures may provide a route for achieving charge transport over long distance by combining multiple charge transport pathways.
Compared to bulk materials, where multiple charge transport pathways are present,20 molecular wires are limited to a single, generally through-bond, pathway. This renders them particularly sensitive to defects or conformational reorganization as these can significantly hamper charge transport by blocking the only pathway available.21,22 Nonetheless, supramolecular wires are interesting as they can accommodate the construction of heterojunctions or other functionality within a 1D framework.23–27 For this reason, the development of molecules capable of combining both through-space and through-bond charge transport is of great interest as this combination may improve the performance and the stability of molecular devices. Along these lines, Chen et al. showed that a through-space charge transport can be significantly more efficient in short π-stacked tetraphenylene bridges than through-bond transport over a similar distance,28 whereas charge transport along the backbone of an oxahelicene comprising 5 conjugated aromatic units was reported to occur efficiently via a through-bond mechanism.29 Nevertheless, there has been no demonstration of combining multiple conductance pathways in a linear non-conjugated molecule to achieve charge transport over long distances. We now show that this can be achieved using aromatic helical foldamer assemblies.
Synthetic foldamers are artificial folded architectures akin to the structures of biopolymers.30,31 Among these, aromatic foldamers – foldamers with aryl groups in their main chain – stand out because their structures are both predictable and stable.32–34 While early studies on aromatic foldamers focused on relatively small molecules, improvements in synthetic and self-assembly fabrication methods now allow for the delivery of engineered large (up to 25 kDa) and robust molecules or molecular assemblies defined with atomic precision across nanometric distances,35,36 aromatic foldamers have been shown to be useful for the purpose of molecular recognition or for biological applications but their potential use in materials remains largely unexplored.31–34 Interestingly, charge transport through a linearly-stacked oligoanthracene foldamer was investigated by Carini et al. at the single molecule level over distances spanning 0.3 to 1.2 nm to reveal a value of β = 0.02 Å−1, which could be promising for applications in molecular electronics.37 Several groups have used helical structures to control photoinduced charge separation and recombination in donor–acceptor couples through folded bridges in solution.38–40 Recent results based on photoinduced electron transfer rates suggest that helically-folded quinolinecarboxamide oligomers (Fig. 1) can mediate charge separation in the excited state over nanometric distances by providing intermediate hopping sites.40,41
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Fig. 1 (a) Chemical formulae of oligoquinoline foldamers employed in this study (Tr = trityl). These foldamers differ in their molecular helix length (n = 4–32) and linker length (m = 1, 2 or 9), and in the anchoring group (thiol or alkyne); (b) schematic (top) and crystal (bottom) structures of helical oligo-quinoline carboxamide foldamers. In the crystal structure representation, isobutoxy side chains and included solvent molecules have been omitted for clarity.51,52 |
Herein, we report a combined experimental and theoretical investigation of charge transport in self-assembled monolayers of helically-organized oligo-quinolinecarboxamide foldamers in the ground state that constitute a first example of a foldamer-based Metal–Organic–Metal (MOM) junction. Conductive-probe AFM (C-AFM) was used to investigate the effects of self-organization on both vertical and horizontal charge transport between a conductive tip and a fixed Au electrode. C-AFM is a versatile technique to determine the resistance across self-assembled monolayers,4,42–44 including complex systems incorporating proteins,45 DNA,46–48 organometallic complexes,49 or fullerenes.50 Whereas we found no evidence of lateral charge transport, vertical charge transport across the length of the foldamer chain was found to be particularly efficient. The results show a remarkably low value for the apparent attenuation factor (β = 0.06 Å−1) in agreement with a mechanism that, according to kinetic Monte Carlo simulations, greatly benefits from the combination of multiple hopping pathways between adjacent as well as remote subunits thanks to charge transfer integrals approaching those found in pentacene and rubrene crystals. These findings show that aromatic helical foldamers provide a new strategy for maximizing charge transport over long distances that is not contingent on extending molecular conjugation or intermolecular packing.
Compounds Q5, Q9, Q17 and Q33 (Fig. 1) constitute a set of well-defined helically-folded oligo-quinolinecarboxamides terminated with a trityl-protected thiol group at the N-terminus (see ESI† for details about the synthesis). Molecular length is determined by increasing the number of quinoline units from n = 5 to 33. The N-terminal benzyl amide group was introduced because of its propensity to form a 90° turn53,54 with respect to the last aryl ring, favoring the orientation of the thiol-bearing alkyl chain parallel to the helix axis so as to allow the helices to stand upright, with low tilt angles with respect to the Au surface. The robustness of these molecular helices both in solution and in the solid state is due to electrostatic repulsions between heteroatoms in adjacent quinoline units, as well as intramolecular hydrogen bonds and aromatic stacking between consecutive turns (Fig. 1b), and has been abundantly demonstrated by X-ray diffraction on single crystals and high-resolution NMR spectroscopy.51,52 The helices are characterized by a helical pitch (vertical rise) of 3.5 Å per turn and a curvature of 2.5 units per turn (as determined from the solid-state structures).52 Considering a linker distance of 0.4 nm, we calculated the overall lengths of Q5, Q9, Q17, and Q33 in their folded conformations to be 1.2, 1.8, 3.1, and 5.7 nm, respectively. No evidence for excitonic interactions between the electronic transitions of the quinoline units, e.g. analogous to those seen in e.g. DNA,55 is observed in the absorption or emission spectra (Fig. S3†).
Dense self-assembled monolayers of the thiols on flat Au(111) substrates were obtained after in situ deprotection of the trityl group in acid followed by incubation at 50 °C for 48 h (see ESI† for experimental details).56 Cyclic voltammetry shows complete passivation of the underlying Au electrode as expected for the formation of dense monolayers (Fig. S5†). Contact angle measurements, ellipsometry, and polarization modulation – IR reflection absorption spectroscopy (PMIRRAS, Fig. S6 and Table S5†) are all in agreement with the formation of monolayers in which the helices are oriented perpendicular to the surface of the substrate. Indeed, a clear linear dependence of the film thickness vs. n is observed for Q9, Q17, and Q33 (Fig. 2), where the intercept gives a linker length (0.3 nm) in agreement with molecular modeling (0.4 nm). In contrast, a monolayer in which the foldamer assemblies lie horizontal to the surface would not provide a regular increase in surface height with increasing foldamer length. The tilt angle of the assembly is calculated to be 35°, as typically observed for alkane-thiols on Au(111) surfaces.57 Furthermore, as expected for the exposure of identical headgroups, the molecular packing generates a hydrophobic surface that is similar for all compounds (Fig. 2). A notable exception to this trend is the shortest foldamer, Q5, for which somewhat higher than expected values of the thickness and contact angle are obtained. Short foldamer sequences possess a low aspect ratio that resembles a disc-like structure compared to the rod-like longer foldamers. Therefore, Q5 may exhibit different surface packing compared to Q9–Q33.
Investigation of the surface topology of Q5–Q33 monolayers was carried out by AFM (Fig. 2b and S7†), which gave no evidence towards the formation of crystalline domains.52 We also observe increasing roughness upon increasing the foldamer length, which may originate from lateral organization of the foldamers due to van der Waals interactions between the alkyl side chains. A comparison between Q9 and Q9m=9 showed that the length of the linker has a clear influence on the film thickness, but that measurements for water contact angle, capacitance, and passivation of the electrode towards an external redox probe are very similar (Table S4, Fig. S5†), suggesting similar surface coverage. Based on this, we chose to use the m = 1 linker for all other compounds because it provides good surface coverage while minimizing contact resistance.58,59
The vertically aligned foldamers on gold form part of a molecular junction designed to probe charge transport across the helical architectures. The circuit is completed using a conductive AFM equipped with a Pt–Ir tip that allows controlling the contact force and applied voltage while monitoring the current across the monolayer (Fig. 3a). Good electrical contact was obtained by applying a light force to the tip (<1.5 nN) in order to avoid molecular compression and monolayer invasion. Upon increasing the tip force to about 4 nN, short-circuit junctions became predominant which indicates deformation of the monolayer or direct contact between the tip and the surface. Current intensity versus applied bias (±1.5 V) curves were collected at different points at the surface, with each point measured in triplicate (see ESI†). To allow comparison between the different samples, all the measurements were conducted with the same tip at the same applied force. Averaged I–V curves for Q9–Q33 are shown in Fig. 3b. The junction resistance is calculated in the region where I scales linearly with the applied bias (±0.3 V), which reduces the effect of fluctuations at higher values of V.
The resistance of the MOM junctions is found to increase with the number of quinoline units, as expected for charge transport through a molecular junction. The resistances obtained from measurements on each SAM are combined in histograms (Fig. 3c), which show a tight distribution for Q9 and Q17, and a broader distribution for Q33.60 In the latter case, the increased roughness of the SAM observed by AFM may explain the broader distribution. Following the discussion by Whitesides and co-workers,61 we use the median of the distribution of the resistance as it is less sensitive to outlying values.62 It is immediately apparent that there is only a very small dependence of the junction resistance on molecular length. A plot of lnR vs. molecular length for the series Q9–Q33 is linear with a slope of 0.06 ± 0.015 Å−1 (Fig. 3d). As discussed in the introduction, such a low value is typical of charge transport by hopping, which must be efficient despite the absence of significant orbital overlap between adjacent quinoline units.
To investigate lateral charge transport, substrates grafted with AQ17 were selected in view of the latter's synthetic accessibility and sufficient foldamer length to allow for electronic interactions between molecules. A 50 nm gold electrode was evaporated onto the modified substrates using a soft PDMS contact shadow mask to protect the monolayer and obtain a sharp edge as described previously (Fig. 5).63 Substrates with a thick (200 nm) layer of SiO2 were used to ensure that no leakage current could flow through the substrate. The samples were mounted on the C-AFM and a conductive tip was used to complete the circuit and allow measurement of I/V curves at varying distances from the fixed Au electrode (Fig. 5c).
The results obtained for the AQ17 monolayer indicated a complete absence, under the experimental conditions, of lateral conductivity in contrast to our previous results using anthracene- or fullerene-containing monolayers. The behavior of the AQ17 monolayer was identical to that of an insulating alkane monolayer on SiO2.63 As a test of the instrumental set-up, control experiments with the 11-azidoundecane monolayer evidenced a semi-logarithmic decrease of the conductivity over a 100 nm region separating the tip from the fixed electrode (Fig. S12†), attributable to a small degree of charge transport by the monolayer or by residual adsorbed water. We therefore attribute the absence of lateral conductivity by the foldamer monolayer to originate from insufficient electronic communication between the adjacent foldamer architectures, either due to low surface density of the foldamers or to intrinsically low values of the lateral charge carrier mobility. The latter explanation seems more plausible in view of the isobutyl side-chains, which prevent close contact of the aromatic regions. Indeed, Mayor, Calame, and co-workers have previously shown that close contact is important for intermolecular charge transport through π-stacking interactions in single molecule-based break-junctions.66 Typical packing of isobutoxy-substituted oligo-quinolinecarboxamide foldamers observed in the solid state shows interdigitation of the isobutoxy chains that prevents lateral contacts, while longitudinal contacts remain possible through end-to-end stacking of the helices.67
In principle, a helical structure allows for both superexchange and hopping mechanisms to take place simultaneously.70,71 To investigate these possibilities, we evaluated the transfer integrals between neighboring and distal units. Not unexpectedly, there is moderately strong through-bond coupling between the i, i + 1 units (92 meV) which allows charges to move along the helix by following the oligoquinoline chain. However, due to the specific spatial arrangement of quinoline units in the helix, there is also strong through-space coupling between non-directly bonded units situated above and below the quinoline plane, i.e. between i, i + 2 (27 meV) and i, i + 3 (48 meV) units (Fig. 6c). This electronic coupling, reported in Table S2,† contributes at least in principle to increasing superexchange-mediated transfer rates, and also gives rise to thermally activated hopping. Indeed, the i, i + 3 coupling of 48 meV is roughly half of the coupling reported at the same level of calculation for one of the best organic semiconductors, rubrene,72 and very similar to couplings present in π-stacked pentacene molecular crystals.73 The coupling between i, i + 4 is instead negligible.
The calculated energetic disorder in the HOMO levels (σε = 127 meV) is larger than the through-bond coupling (Ji,i+1 = 92 meV for the n = 48 helix), hinting at the predominance of hopping for long architectures. Accordingly, we studied hole transport using Kinetic Monte Carlo (KMC, see ESI† for details of calculations) simulations based on the Marcus hopping model, with the objective of disentangling the contributions of the different electronic couplings. We compared three different situations: one where only the nearest-neighbor coupling is switched on (“bond”), one where only the two through-space couplings are active (“space”), and finally one where all the couplings are present (“bond” + “space”), both in presence and in absence of energetic disorder. The calculated percolation times, directly proportional to the electric resistance, are plotted in Fig. 6 for helices of increasing length. As expected from the hopping model, the times increase with length, confirming the consistency of the KMC results. Surprisingly, the through-bond percolation times are always larger than the through-space ones (even in absence of disorder) indicating that the larger number of through-space pathways is more important to charge transport than the larger through-bond coupling. This effect is of course magnified when disorder is present (Fig. 6e). In addition, percolation rates when both mechanisms are present are not simply the sum of the rates of the individual contributions. Instead, they show a strongly synergistic effect arising from the combination of the two mechanisms, resulting in calculated hole mobilities of 0.1–1 cm2 V−1 s−1, depending on the amount of disorder.
Footnote |
† Electronic supplementary information (ESI) available: Details of the synthesis of compounds Q5–Q33 and AQ5–AQ9, protocols for surface modification and characterization, I/V curves for vertical and horizontal charge transport mechanisms and theoretical calculations. See DOI: 10.1039/c7sc03341a |
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