Issue 5, 2018
From the journal:

Organic Chemistry Frontiers

tert-Butyl peroxybenzoate mediated formation of 3-alkylated quinolines from N-propargylamines via a cascade radical addition/cyclization reaction†

Wei Chen,a   Yicheng Zhang,ab   Pinhua Li ORCID logo *a  and  Lei Wang ORCID logo *ac  

* Corresponding authors

a Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China
E-mail: leiwang@chnu.edu.cn
Fax: +86-561-309-0518
Tel: +86-561-380-2069

b School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, P. R. China

c State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China

Abstract

A tert-butyl peroxybenzoate (TBPB) mediated direct functionalization of N-propargyl aromatic amine derivatives with ethers has been developed. This procedure provides a new strategy toward the synthesis of 3-alkylated quinolines in one step via a domino radical addition/cyclization reaction under metal-free conditions.

Graphical abstract: tert-Butyl peroxybenzoate mediated formation of 3-alkylated quinolines from N-propargylamines via a cascade radical addition/cyclization reaction

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Article information

DOI
https://doi.org/10.1039/C7QO01052D
Article type
Research Article
Submitted
24 Nov 2017
Accepted
30 Nov 2017
First published
01 Dec 2017

Org. Chem. Front., 2018,5, 855-859

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tert-Butyl peroxybenzoate mediated formation of 3-alkylated quinolines from N-propargylamines via a cascade radical addition/cyclization reaction

W. Chen, Y. Zhang, P. Li and L. Wang, Org. Chem. Front., 2018, 5, 855 DOI: 10.1039/C7QO01052D

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