Issue 3, 2017

Formylation of phenols using formamidine acetate

Abstract

We report a new method to formylate phenol derivatives using formamidine acetate and acetic anhydride. This general-purpose transformation is a significant improvement over many other methods and does not require high temperatures or the addition of strong acid or base. Mono-, di-, and tri-formylated product can be obtained, depending on the substrate and conditions used.

Graphical abstract: Formylation of phenols using formamidine acetate

Supplementary files

Article information

Article type
Communication
Submitted
25 Nov 2016
Accepted
14 Dec 2016
First published
21 Dec 2016

Org. Biomol. Chem., 2017,15, 581-583

Formylation of phenols using formamidine acetate

S. H. M. Mehr, H. Depmeier, K. Fukuyama, M. Maghami and M. J. MacLachlan, Org. Biomol. Chem., 2017, 15, 581 DOI: 10.1039/C6OB02727J

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