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Correction: The medicinal chemist's toolbox for late stage functionalization of drug-like molecules
Tim
Cernak
*a,
Kevin D.
Dykstra
b,
Sriram
Tyagarajan
b,
Petr
Vachal
b and
Shane W.
Krska
b
aMerck Research Laboratories, Discovery Chemistry - Automation & Capabilities Enhancement, 33 Avenue Louis Pasteur, BMB2-116B, Boston, Massachusetts 02115, USA. E-mail: timothy_cernak@merck.com; Tel: +1 617 992 2366
bMerck Research Laboratories, Discovery Chemistry - Automation & Capabilities Enhancement, Rahway, New Jersey, USA
First published on 10th March 2017
Abstract
Correction for ‘The medicinal chemist's toolbox for late stage functionalization of drug-like molecules’ by Tim Cernak et al., Chem. Soc. Rev., 2016, 45, 546–576.
Clopidogrel (compound 105 in Fig. 10) was mistakenly drawn with a meta-chloro substituent whereas the actual drug has an ortho-chloro substituent, as shown in the corrected figure below. Since compound 105 was used as a hypothetical substrate with which to demonstrate the strategy of late-stage functionalization, the proposed reactivity of C–H bonds will be affected by this change. The correct structure with the updated hypothetical late-stage functionalization strategy is shown in the corrected figure below. The authors apologize for any inconvenience this may have caused.
The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.
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