Issue 60, 2017
From the journal:

Chemical Communications

A divergent [5+2] cascade approach to bicyclo[3.2.1]octanes: facile synthesis of ent-kaurene and cedrene-type skeletons†

Chi He,a   Zengbing Bai,‡b   Jialei Hu,‡a   Bingnan Wang,a   Hujun Xie, ORCID logo *c   Lei Yu ORCID logo *b  and  Hanfeng Ding ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Zhejiang University, Hangzhou 310058, China
E-mail: hfding@zju.edu.cn

b School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China
E-mail: yulei@yzu.edu.cn

c Department of Applied Chemistry, Zhejiang Gongshang University, Hangzhou 310018, China
E-mail: hujunxie@gmail.com

Abstract

A solvent-dependent oxidative dearomatization-induced divergent [5+2] cascade approach to bicyclo[3.2.1]octanes was described. This novel protocol enables a facile synthesis of a series of diversely functionalized ent-kaurene and cedrene-type skeletons in good yields and excellent diastereoselectivities.

Graphical abstract: A divergent [5+2] cascade approach to bicyclo[3.2.1]octanes: facile synthesis of ent-kaurene and cedrene-type skeletons

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Article information

DOI
https://doi.org/10.1039/C7CC04292B
Article type
Communication
Submitted
03 Jun 2017
Accepted
05 Jul 2017
First published
05 Jul 2017

Chem. Commun., 2017,53, 8435-8438

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A divergent [5+2] cascade approach to bicyclo[3.2.1]octanes: facile synthesis of ent-kaurene and cedrene-type skeletons

C. He, Z. Bai, J. Hu, B. Wang, H. Xie, L. Yu and H. Ding, Chem. Commun., 2017, 53, 8435 DOI: 10.1039/C7CC04292B

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