Issue 26, 2016
From the journal:

Journal of Materials Chemistry B

Irreversible destruction of amyloid fibril plaques by conjugated polymer based fluorogenic nanogrenades†

Wei-Tao Dou,a   Ying Lv,b   Chunyan Tan,*b   Guo-Rong Chena  and  Xiao-Peng He*a  

* Corresponding authors

a Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, P. R. China
E-mail: xphe@ecust.edu.cn

b The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P. R. China
E-mail: tancy@sz.tsinghua.edu.cn

Abstract

Supramolecular assembly between conjugated polymers and fluorescent dyes produces a unique class of fluorogenic “nanogrenades”. These nanomaterials have shown the ability to image as well as irreversibly destruct amyloid β fibril plaques by simple light irradiation.

Graphical abstract: Irreversible destruction of amyloid fibril plaques by conjugated polymer based fluorogenic nanogrenades

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Article information

DOI
https://doi.org/10.1039/C6TB01351A
Article type
Communication
Submitted
30 May 2016
Accepted
01 Jun 2016
First published
01 Jun 2016

J. Mater. Chem. B, 2016,4, 4502-4506

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Irreversible destruction of amyloid fibril plaques by conjugated polymer based fluorogenic nanogrenades

W. Dou, Y. Lv, C. Tan, G. Chen and X. He, J. Mater. Chem. B, 2016, 4, 4502 DOI: 10.1039/C6TB01351A

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