A novel straightforward method for the synthesis of 2,3-disubstituted imidazo[1,2-a]pyridine derivatives in water as a truly safe and cheap reaction medium was developed. Hence, N-alkyl pyridinium and S-alkyl thiouronium salts were reacted in the presence of NaHCO3 as a mild base in water to produce imidazo[1,2-a]pyridines in moderate to excellent yields.
![Graphical abstract: One-step synthesis of imidazo[1,2-a]pyridines in water](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C6RA17065J&imageInfo.ImageIdentifier.Year=2016)
H. Zali-Boeini, N. Norastehfar and H. Amiri Rudbari, RSC Adv., 2016, 6, 81943 DOI: 10.1039/C6RA17065J
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