Issue 43, 2016

Copper(ii)-catalyzed remote sulfonylation of aminoquinolines with sodium sulfinates via radical coupling

Abstract

The efficient remote sulfonylation of N-(quinolin-8-yl)benzamide derivatives at the C5 position has been well developed. The reaction generates environmentally benign byproducts by utilizing stable and safe sodium sulfinates as sulfide sources. A series of N-(5-(phenylsulfonyl)quinolin-8-yl)benzamide derivatives were successfully obtained in moderate to high yields. In particular, they are less unpleasantly odorous and more environmentally friendly than previous means.

Graphical abstract: Copper(ii)-catalyzed remote sulfonylation of aminoquinolines with sodium sulfinates via radical coupling

Supplementary files

Article information

Article type
Communication
Submitted
14 Feb 2016
Accepted
02 Apr 2016
First published
05 Apr 2016

RSC Adv., 2016,6, 37173-37179

Copper(II)-catalyzed remote sulfonylation of aminoquinolines with sodium sulfinates via radical coupling

C. Xia, K. Wang, J. Xu, Z. Wei, C. Shen, G. Duan, Q. Zhu and P. Zhang, RSC Adv., 2016, 6, 37173 DOI: 10.1039/C6RA04013F

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