Zhen-Hua Wang, Zhi-Jun Wu, Deng-Feng Yue, Yong You, Xiao-Ying Xu, Xiao-Mei Zhang and Wei-Cheng Yuan
Org. Biomol. Chem., 2016,14, 6568-6576
DOI:
10.1039/C6OB01191H,
Paper
An organocatalyzed direct asymmetric vinylogous Michael addition reaction of α,β-unsaturated γ-butyrolactam to 2-enoylpyridines has been developed with a chiral bifunctional amine-squaramide as the catalyst. This approach provides easy access to a series of optically active α,β-unsaturated γ-substituted butyrolactams in high yields (up to 99%) with excellent diastereoselectivities (up to >99 : 1) and enantioselectivities (up to >99% ee).
