Sudhakar Athe, Ashish Sharma, Kanakaraju Marumudi and Subhash Ghosh
Org. Biomol. Chem., 2016,14, 6769-6779
DOI:
10.1039/C6OB01007E,
Paper
A concise synthetic strategy has been developed for the synthesis of the macrolactone core 2 of a unique polyketide callyspongiolide 1. The key features of the strategy included an Evan's asymmetric alkylation, diastereoselective Michael type alkylation, Brown's asymmetric allylation reaction, an allylic alkylation of an activated Z-allylic alcohol and an intramolecular Z-selective intramolecular H–W–E olefination.
