Issue 29, 2016
From the journal:

Organic & Biomolecular Chemistry

One-pot sequential asymmetric hydrogenation of β-aryl-β-aryloxy acroleins†

Yufeng Liu,a   Jianzhong Chen,b   Zhenfeng Zhang,*c   Jian Qin,a   Min Zhao*a  and  Wanbin Zhang*bc  

* Corresponding authors

a School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China

b School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
E-mail: wanbin@sjtu.edu.cn
Web: http://wanbin.sjtu.edu.cn
Fax: +86-21-5474-3265
Tel: +86-21-5474-3265

c School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China

Abstract

A one-pot sequential asymmetric hydrogenation of β-aryl-β-aryloxy acroleins has been realized for the preparation of chiral 3-aryl-3-aryloxy alcohols with excellent yields and good enantioselectivities. This methodology can be employed in new synthetic routes for the synthesis of fluoxetine, atomoxetine, and related analogues.

Graphical abstract: One-pot sequential asymmetric hydrogenation of β-aryl-β-aryloxy acroleins

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Article information

DOI
https://doi.org/10.1039/C6OB00871B
Article type
Paper
Submitted
22 Apr 2016
Accepted
24 Jun 2016
First published
28 Jun 2016

Org. Biomol. Chem., 2016,14, 7099-7102

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One-pot sequential asymmetric hydrogenation of β-aryl-β-aryloxy acroleins

Y. Liu, J. Chen, Z. Zhang, J. Qin, M. Zhao and W. Zhang, Org. Biomol. Chem., 2016, 14, 7099 DOI: 10.1039/C6OB00871B

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