Issue 27, 2016

A strategy for the synthesis of hydrophobic proteins and glycoproteins

Abstract

Our synthetic strategy for the hydrophobic glycoprotein is summarized. The reverse-polarity protection strategy, in which the side chain carboxy group is protected as a basic picolyl ester, combined with the O-acylisopeptide method proved to be efficient for the preparation of the hydrophobic glycoprotein by ligation methods, and would be applicable for the synthesis of membrane proteins in the future.

Graphical abstract: A strategy for the synthesis of hydrophobic proteins and glycoproteins

Article information

Article type
Review Article
Submitted
18 Apr 2016
Accepted
31 May 2016
First published
31 May 2016

Org. Biomol. Chem., 2016,14, 6368-6374

A strategy for the synthesis of hydrophobic proteins and glycoproteins

H. Hojo, Org. Biomol. Chem., 2016, 14, 6368 DOI: 10.1039/C6OB00827E

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