Issue 6, 2016
From the journal:

Organic & Biomolecular Chemistry

Ionic liquid supported organotin reagents to prepare molecular imaging and therapy agents†

Holisoa Rajerison,*a   Djibril Faye,b   Aurélia Roumesy,a   Nicolas Louaisil,c   Fabien Boeda,c   Alain Faivre-Chauvet,a   Jean-François Gestin*a  and  Stéphanie Legoupy*b  

* Corresponding authors

a Université de Nantes, CRCNA, UMR 892 INSERM-6299 CNRS, 8 Quai Moncousu, 44000 Nantes, France
E-mail: holisoa.rajerison@univ-nantes.fr, jfgestin@nantes.inserm.fr

b Université d'Angers, Laboratoire MOLTECH-Anjou, CNRS UMR 6200, 2 Boulevard Lavoisier, F-49045 Angers, France
E-mail: stephanie.legoupy@univ-angers.fr

c LUNAM Université, Université du Maine, CNRS UMR 6283, Institut des Molécules et Matériaux du Mans (IMMM), 72085 Le Mans Cedex 09, France

Abstract

Efficiency of ionic liquid supported organotin reagents in halodemetalation reaction has been investigated. High radiochemical yields of astatinated and iodinated compounds have been obtained using simple work-up procedure. This methodology represents a straightforward approach for the preparation of molecular imaging and therapy agents in nuclear medicine.

Graphical abstract: Ionic liquid supported organotin reagents to prepare molecular imaging and therapy agents

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Article information

DOI
https://doi.org/10.1039/C5OB02459E
Article type
Paper
Submitted
01 Dec 2015
Accepted
12 Jan 2016
First published
12 Jan 2016

Org. Biomol. Chem., 2016,14, 2121-2126

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Ionic liquid supported organotin reagents to prepare molecular imaging and therapy agents

H. Rajerison, D. Faye, A. Roumesy, N. Louaisil, F. Boeda, A. Faivre-Chauvet, J. Gestin and S. Legoupy, Org. Biomol. Chem., 2016, 14, 2121 DOI: 10.1039/C5OB02459E

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