F. S. Ekholm, H. Pynnönen, A. Vilkman, J. Koponen, J. Helin and T. Satomaa
Org. Biomol. Chem., 2016,14, 849-852
DOI:
10.1039/C5OB02133B,
Communication
One of the most successful bioconjugation strategies to date is the copper(I)-catalyzed cycloaddition reaction (CuAAC), however, the typically applied reaction conditions have been found to degrade sensitive biomolecules. Herein, we present a water soluble copper chelator which can be utilized to protect biomolecules from copper induced degradation.
