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Metal-free para-toluenesulfonic acid mediated straightforward synthesis of hitherto unreported tetrasubstituted thiophenes has been achieved in quantitative yields by chemo- and regioselective dehydrative cyclization of α,α′-bis(β-oxodithioesters) at room temperature. Notably, the dithioester group at the 4-position of the thiophene ring has been further transformed to a thiazoline group.

Graphical abstract: Metal-free Brønsted acid mediated synthesis of fully substituted thiophenes via chemo- and regioselective intramolecular cyclization of α,α′-bis(β-oxodithioesters) at room temperature

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