Issue 8, 2016

Point of care testing of phospholipase A2 group IIA for serological diagnosis of rheumatoid arthritis

Abstract

Secretory phospholipase A2 group IIA (sPLA2-IIA) was examined as a point of care marker for determining disease activity in rheumatoid (RA) and psoriatic (PsA) arthritis. Serum concentration and activity of sPLA2-IIA were measured using in-house antibodies and a novel point of care lateral flow device assay in patients diagnosed with varying severities of RA (n = 30) and PsA (n = 25) and found to correlate strongly with C-reactive protein (CRP). Levels of all markers were elevated in patients with active RA over those with inactive RA as well as both active and inactive PsA, indicating that sPLA2-IIA can be used as an analogue to CRP for RA diagnosis at point of care.

Graphical abstract: Point of care testing of phospholipase A2 group IIA for serological diagnosis of rheumatoid arthritis

Supplementary files

Article information

Article type
Communication
Submitted
27 Nov 2015
Accepted
25 Jan 2016
First published
01 Feb 2016

Nanoscale, 2016,8, 4482-4485

Point of care testing of phospholipase A2 group IIA for serological diagnosis of rheumatoid arthritis

N. J. Liu, R. Chapman, Y. Lin, J. Mmesi, A. Bentham, M. Tyreman, S. Abraham and M. M. Stevens, Nanoscale, 2016, 8, 4482 DOI: 10.1039/C5NR08423G

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