Issue 14, 2016
From the journal:

Nanoscale

Stem cell secretome-rich nanoclay hydrogel: a dual action therapy for cardiovascular regeneration†

Renae Waters,a   Settimio Pacelli,a   Ryan Maloney,a   Indrani Medhi,b   Rafeeq P. H. Ahmedc  and  Arghya Paul*a  

* Corresponding authors

a BioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering Graduate Program, School of Engineering, University of Kansas, Lawrence, KS, USA
E-mail: arghyapaul@ku.edu

b SRM University, Kattankulathur 603203, Tamilnadu, India

c Department of Pathology, University of Cincinnati, 231-Albert Sabin Way, Cincinnati 45267, OH, USA

Abstract

A nanocomposite hydrogel with photocrosslinkable micro-porous networks and a nanoclay component was successfully prepared to control the release of growth factor-rich stem cell secretome. The proven pro-angiogenic and cardioprotective potential of this new bioactive system provides a valuable therapeutic platform for cardiac tissue repair and regeneration.

Graphical abstract: Stem cell secretome-rich nanoclay hydrogel: a dual action therapy for cardiovascular regeneration

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Article information

DOI
https://doi.org/10.1039/C5NR07806G
Article type
Communication
Submitted
07 Nov 2015
Accepted
04 Feb 2016
First published
05 Feb 2016

Nanoscale, 2016,8, 7371-7376

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Stem cell secretome-rich nanoclay hydrogel: a dual action therapy for cardiovascular regeneration

R. Waters, S. Pacelli, R. Maloney, I. Medhi, R. P. H. Ahmed and A. Paul, Nanoscale, 2016, 8, 7371 DOI: 10.1039/C5NR07806G

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