Issue 9, 2016
From the journal:

New Journal of Chemistry

New generation of camptothecin derivatives spontaneously alkylating DNA†

Beata Naumczuk,a   Katarzyna Wiktorska,b   Katarzyna Lubelska,b   Robert Kawęcki,c   Wojciech Bocian,ab   Elżbieta Bednarek,b   Jerzy Sitkowski,ab   Zdzisław Chilmonczykb  and  Lech Kozerski*ab  

* Corresponding authors

a Institute of Organic Chemistry, Polish Academy of Sciences, 01-224 Warszawa, Kasprzaka 44, Poland
E-mail: lech.kozerski@icho.edu.pl
Tel: +48 22 343 20 18

b National Medicines Institute, 00-725 Warszawa, Chełmska 30/34, Poland

c Siedlce University, 08-110 Siedlce, 3 Maja 54, Poland

Abstract

9-Aminomethyl derivatives of 7-ethyl-10-hydroxycamptothecin were synthesized. Interaction with a natural DNA octamer was checked using 1H NMR, PFGSE NMR and MALDI-TOF experiments, which proved covalent binding. Compounds were tested against human cancer cell lines in vitro. All compounds show high activity comparable to SN38. The obtained products are well soluble in water.

Graphical abstract: New generation of camptothecin derivatives spontaneously alkylating DNA

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Article information

DOI
https://doi.org/10.1039/C6NJ01217E
Article type
Paper
Submitted
18 Apr 2016
Accepted
25 Jul 2016
First published
26 Jul 2016

New J. Chem., 2016,40, 7978-7985

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New generation of camptothecin derivatives spontaneously alkylating DNA

B. Naumczuk, K. Wiktorska, K. Lubelska, R. Kawęcki, W. Bocian, E. Bednarek, J. Sitkowski, Z. Chilmonczyk and L. Kozerski, New J. Chem., 2016, 40, 7978 DOI: 10.1039/C6NJ01217E

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