Issue 7, 2016

Heteroleptic Cu(ii)–polypyridyl complexes as photonucleases

Abstract

A series of heteroleptic Cu(II)–polypyridyl complexes with terpyridine (3N)/imidazole (2N) backbones and appended with pyridyl, 2-naphthyl, 9-anthryl and 1-pyrenyl groups are synthesized and evaluated for their photonuclease activity. An array of techniques viz. UV-vis, fluorescence, circular dichroism and thermal denaturation established strong DNA binding affinity (Kb = ∼104–106 M−1) and the binding modes were correlated with molecular docking studies. Photonuclease efficiency exceeded 90% for all the complexes under identical conditions. Interestingly, DNA binding propensity and photonuclease efficiency followed the increasing size, planarity, aromaticity, π-Stacking ability and hydrophobicity of the peripheral moiety.

Graphical abstract: Heteroleptic Cu(ii)–polypyridyl complexes as photonucleases

Supplementary files

Article information

Article type
Paper
Submitted
06 Feb 2016
Accepted
05 May 2016
First published
06 May 2016

New J. Chem., 2016,40, 5906-5913

Heteroleptic Cu(II)–polypyridyl complexes as photonucleases

V. Singh, K. Sharma, B. Shankar, S. K. Awasthi and R. D. Gupta, New J. Chem., 2016, 40, 5906 DOI: 10.1039/C6NJ00409A

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