Eco-friendly Suzuki–Miyaura coupling of arylboronic acids to aromatic ketones catalyzed by the oxime-palladacycle in biosolvent 2-MeTHF

Abstract

Oxime-palladacycle catalyzed Suzuki–Miyaura cross-coupling reaction of acid chlorides and arylboronic acids to yield aryl ketones was developed. The remarkable benefit of this method is the use of water immiscible (practically) 2-MeTHF as solvent, which provides easy isolation of the crude reaction mixture just by separation of 2-MeTHF–water layers, and then evaporation of 2-MeTHF. Moreover, the use of relatively equal proportion of substrates and less generation of side products make the method highly atom economic.