Issue 5, 2016

Label-free technologies for target identification and validation

Abstract

Phenotypic screening is a powerful strategy for identifying active molecules with particular biological effects in cellular or animal disease models. Functionalized chemical probes have been instrumental in revealing new targets and confirming target engagement. However, substantial effort and resources are required to design and synthesize these bioactive probes. In contrast, label-free technologies have the advantage of bypassing the need for chemical probes. Here we highlight the recent developments in label-free methods and discuss the strengths and limitations of each approach.

Graphical abstract: Label-free technologies for target identification and validation

Article information

Article type
Review Article
Submitted
21 Jan 2016
Accepted
20 Mar 2016
First published
22 Mar 2016

Med. Chem. Commun., 2016,7, 769-777

Label-free technologies for target identification and validation

J. Li, H. Xu, G. M. West and L. H. Jones, Med. Chem. Commun., 2016, 7, 769 DOI: 10.1039/C6MD00045B

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