Visible-light-activated copper(I) catalyzed oxidative Csp–Csp cross-coupling reaction: efficient synthesis of unsymmetrical conjugated diynes without ligands and base

Arunachalam Sagadevan; Ping-Chiang Lyu; Kuo Chu Hwang

doi:10.1039/C6GC01463A

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Visible-light-activated copper(i) catalyzed oxidative C_sp–C_sp cross-coupling reaction: efficient synthesis of unsymmetrical conjugated diynes without ligands and base†

Arunachalam Sagadevan,^a Ping-Chiang Lyu^b and Kuo Chu Hwang*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan, Republic of China

^b Institute of Bioinformatics and Structural Biology and College of Life Sciences, National Tsing Hua University, Hsinchu, Taiwan, Republic of China
E-mail: kchwang@mx.nthu.edu.tw
Fax: +886 35711082

Abstract

A novel visible-light-promoted copper-catalysed process for the C_sp–C_sp cross-coupling reaction of terminal alkynes at room temperature is described. The current photochemical method is simple, highly functional group compatible, and more viable towards the construction of bio-active 1,3-unsymmetrical conjugated diynes without the need of bases/ligands, additives and expensive palladium/gold catalysts.

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Article information

DOI: https://doi.org/10.1039/C6GC01463A
Article type: Communication
Submitted: 28 May 2016
Accepted: 27 Jun 2016
First published: 28 Jun 2016

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Green Chem., 2016,18, 4526-4530

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Visible-light-activated copper(I) catalyzed oxidative C_sp–C_sp cross-coupling reaction: efficient synthesis of unsymmetrical conjugated diynes without ligands and base

A. Sagadevan, P. Lyu and K. C. Hwang, Green Chem., 2016, 18, 4526 DOI: 10.1039/C6GC01463A

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