Anti-hyperlipidemia and antioxidant activities of Amygdalus pedunculata seed oil

Abstract

This study attempts to evaluate the beneficial effects of Amygdalus pedunculata seed oil (AO) on the lipid profile and antioxidant status of high-fat fed rats and D-galactose (D-gal)-induced oxidative mice. The anti-hyperlipidemia effects of AO were evaluated. AO supplementation (2%, 4%, and 8%) for three weeks significantly decreased the total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL) levels and increased the high-density lipoprotein (HDL) levels in the high fat diet rats unlike in the model group. The antioxidant activities of AO were determined in the D-gal-injected mice. Results showed that AO (2%, 4%, and 8%) enhanced the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), as well as lowered the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MAD) in the liver of D-gal-injected mice. Compared with olive oil (OO) and rapeseed oil (RSO), the results of tests indicated that AO lowered the hyperlipidemia risk factors by improving plasma antioxidant defenses and lipid profiles.