Issue 7, 2016
From the journal:

Chemical Communications

A mild hydration of nitriles catalysed by copper(ii) acetate†

Patricia Marcé,a   James Lynch,a   A. John Blackerb  and  Jonathan M. J. Williams*a  

* Corresponding authors

a Department of Chemistry, University of Bath, Claverton Down, England
E-mail: J.M.J.Williams@bath.ac.uk

b Institute of Process Research & Development, School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK

Abstract

A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.

Graphical abstract: A mild hydration of nitriles catalysed by copper(ii) acetate

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5CC08714G
Article type
Communication
Submitted
20 Oct 2015
Accepted
20 Nov 2015
First published
20 Nov 2015

Chem. Commun., 2016,52, 1436-1438

Author version available

Download author version (PDF)

Permissions

Request permissions

A mild hydration of nitriles catalysed by copper(II) acetate

P. Marcé, J. Lynch, A. J. Blacker and J. M. J. Williams, Chem. Commun., 2016, 52, 1436 DOI: 10.1039/C5CC08714G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements