Simultaneous electrochemical quantification of naproxen, acetaminophen and diclofenac using a bare carbon paste electrode

Abstract

It is shown, for the first time, that a bare carbon paste electrode can be used for the simultaneous quantification of anti-inflammatory drugs: naproxen (NPX), diclofenac (DCF) and acetaminophen (ACT) in aqueous media. The analytical features are: 19 ± 7, 4.1 ± 1.9 and 3.7 ± 1.5 μM as detection limits of DCF, NPX and ACT, respectively, while the sensitivity of this quantification was 93.0 ± 0.7, 40.0 ± 0.3, and 54.0 ± 1.8 μA mM⁻¹ for ACT, NPX and DCF, respectively. The analytical performance of this electrode is compared with that reported for the quantification of these drugs using HPLC, diffuse reflectance photometry, and other electrodes.