Issue 113, 2015
From the journal:

RSC Advances

Novel bivalent spermine-based neutral neogalactolipids for modular gene delivery systems†

E. A. Ivanova,a   A. V. Filatov,b   N. G. Morozova,a   M. A. Zenkovab  and  M. A. Maslov*a  

* Corresponding authors

a Lomonosov Moscow University of Fine Chemical Technologies (MITHT), 86 Vernadskogo ave., Moscow, 119571 Russian Federation
E-mail: mamaslov@mail.ru
Fax: +7 4959368901
Tel: +7 4959368903

b Institute of Chemical Biology and Fundamental Medicine SB RAS, 8 Lavrentieva ave., Novosibirsk, Russian Federation
E-mail: marzen@niboch.nsc.ru
Fax: +7 3833635153
Tel: +7 3833635160

Abstract

New bivalent spermine-based neutral neogalactolipids have been synthesized to develop effective modular gene delivery systems (MGDS) targeting hepatocyte asialoglycoprotein receptors. MGDS composed of new neogalactolipids, cationic gemini-amphiphile, and DOPE were agglutinated in the presence of lectin RCA120 and provided efficient delivery of fluorescently-labeled oligodeoxyribonucleotides into HepG2 cells.

Graphical abstract: Novel bivalent spermine-based neutral neogalactolipids for modular gene delivery systems

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Article information

DOI
https://doi.org/10.1039/C5RA17389B
Article type
Communication
Submitted
27 Aug 2015
Accepted
26 Oct 2015
First published
26 Oct 2015

RSC Adv., 2015,5, 93262-93266

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Novel bivalent spermine-based neutral neogalactolipids for modular gene delivery systems

E. A. Ivanova, A. V. Filatov, N. G. Morozova, M. A. Zenkova and M. A. Maslov, RSC Adv., 2015, 5, 93262 DOI: 10.1039/C5RA17389B

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