Issue 103, 2015
From the journal:

RSC Advances

Silver-catalyzed direct spirocyclization of alkynes with thiophenols: a simple and facile approach to 3-thioazaspiro[4,5]trienones†

Huanhuan Cui,a   Wei Wei,*a   Daoshan Yang,a   Jimei Zhang,a   Zhihong Xu,a   Jiangwei Wena  and  Hua Wang*a  

* Corresponding authors

a The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong, China
E-mail: weiweiqfnu@163.com, huawang_qfnu@126.com
Web: http://wang.qfnu.edu.cn

Abstract

A new and convenient silver-catalyzed direct oxidative spirocyclization of alkynes with thiophenols is described. This methodology provides a simple and practical approach to various 3-thioazaspiro[4,5]trienones in moderate to good yields with high atom efficiency and excellent functional group tolerance.

Graphical abstract: Silver-catalyzed direct spirocyclization of alkynes with thiophenols: a simple and facile approach to 3-thioazaspiro[4,5]trienones

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Article information

DOI
https://doi.org/10.1039/C5RA16548B
Article type
Paper
Submitted
17 Aug 2015
Accepted
30 Sep 2015
First published
30 Sep 2015

RSC Adv., 2015,5, 84657-84661

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Silver-catalyzed direct spirocyclization of alkynes with thiophenols: a simple and facile approach to 3-thioazaspiro[4,5]trienones

H. Cui, W. Wei, D. Yang, J. Zhang, Z. Xu, J. Wen and H. Wang, RSC Adv., 2015, 5, 84657 DOI: 10.1039/C5RA16548B

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