Issue 92, 2015
From the journal:

RSC Advances

Low-dose HSP90 inhibitors DPB and AUY-922 repress apoptosis in HUVECs†

Su-Yun Bai,ac   Li-Qi Yao,a   Le Su,a   Shang-Li Zhang,a   Bao-Xiang Zhao*b  and  Jun-Ying Miao*a  

* Corresponding authors

a Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, P. R. China
E-mail: miaojy@sdu.edu.cn
Fax: +86 531 88565610
Tel: +86 531 88364929

b Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China
E-mail: bxzhao@sdu.edu.cn

c School of Basic Medical Sciences, Taishan Medical University, Taian 271000, P. R. China

Abstract

In this study, we found that low-dose HSP90 inhibitors DPB and AUY-922 could unexpectedly restrain apoptosis in HUVECs. This hormesis was accompanied by the increase of p-AKT1. Our findings could have significant implications for the administration of HSP90 inhibitors in vascular diseases and cancer.

Graphical abstract: Low-dose HSP90 inhibitors DPB and AUY-922 repress apoptosis in HUVECs

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Article information

DOI
https://doi.org/10.1039/C5RA10989B
Article type
Communication
Submitted
10 Jun 2015
Accepted
03 Sep 2015
First published
03 Sep 2015

RSC Adv., 2015,5, 75753-75755

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Low-dose HSP90 inhibitors DPB and AUY-922 repress apoptosis in HUVECs

S. Bai, L. Yao, L. Su, S. Zhang, B. Zhao and J. Miao, RSC Adv., 2015, 5, 75753 DOI: 10.1039/C5RA10989B

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