Modulating the photo-exciting process of photosensitizer to improve in vitro phototoxicity by preparing its self-assembly nanostructures

Abstract

A series of hypocrellin A (HA) self-assembled nanostructures were prepared by controlling the charge properties of drugs and the ion strength of the environment. Comparative studies with nanostructures and HA have demonstrated that the self-assembled effect on the HA molecule significantly enhances its water dispersion ability, ¹O₂ generation efficiency and, thereby, the in vitro phototoxicity to human cervical carcinoma (HeLa) cells.