The structural and electronic impact on the photophysical and biological properties of a series of CuI and AgI complexes with triphenylphosphine and pyrimidine-type thiones

Panagiotis A. Papanikolaou; Anastasios G. Papadopoulos; Eleni G. Andreadou; Antonios Hatzidimitriou; Philip J. Cox; Anastasia A. Pantazaki; Paraskevas Aslanidis

doi:10.1039/C4NJ02203C

The structural and electronic impact on the photophysical and biological properties of a series of Cu^I and Ag^I complexes with triphenylphosphine and pyrimidine-type thiones†

Panagiotis A. Papanikolaou,*^a Anastasios G. Papadopoulos,*^b Eleni G. Andreadou,^c Antonios Hatzidimitriou,^a Philip J. Cox,^d Anastasia A. Pantazaki^c and Paraskevas Aslanidis*^a

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* Corresponding authors

^a Aristotle University of Thessaloniki, Department of Chemistry, Laboratory of Inorganic Chemistry, P.O.B. 135, GR-541 24 Thessaloniki, Greece
E-mail: panpapan@chem.auth.gr, hatzidim@chem.auth.gr, aslanidi@chem.auth.gr
Fax: +30 2310 997738

^b Aristotle University of Thessaloniki, Department of Chemistry, Laboratory of Applied Quantum Chemistry, P.O.B. 135, GR-541 24 Thessaloniki, Greece
E-mail: anastp@chem.auth.gr
Fax: +30 2310 997738

^c Aristotle University of Thessaloniki, Department of Chemistry, Laboratory of Biochemistry, P.O.B. 135, GR-541 24 Thessaloniki, Greece
E-mail: natasa@chem.auth.gr

^d School of Pharmacy, The Robert Gordon University, Schoolhill, Aberdeen AB10 1FR, Scotland, UK
E-mail: p.j.cox@rgu.ac.uk

Abstract

Four Cu^I and three Ag^I mixed–ligand complexes containing a heterocyclic pyrimidine-type thione (pymtH = pyrimidine-2-thione or dmpymtH = 4,6-dimethyl-pyrimidine-2-thione) and triphenylphosphine (PPh₃) have been synthesized and structurally characterized. All copper and two of the silver compounds, namely [Cu(PPh₃)₂(pymtH)₂]BF₄ (1), [Cu(PPh₃)₃(pymtH)]BF₄ (2), [Cu(PPh₃)₂(dmpymtH)₂]BF₄ (3), [Cu(PPh₃)₃(dmpymtH)]BF₄ (4), [Ag(PPh₃)₃(pymtH)]NO₃ (5) and [Ag(PPh₃)₃(dmpymtH)]NO₃ (6), reveal a tetrahedral coordination environment while [Ag(PPh₃)₂(pymtH)]NO₃ (7) preferentially adopts a trigonal planar arrangement. The stoichiometry of the isolated silver complexes does not always follow the respective stoichiometries of the synthetic procedures. The photophysical properties of all the isolated products have been evaluated. In solution, phosphine derived emission is detected while in the solid state only [Cu(PPh₃)₃(dmpymtH)]BF₄ (4) emits from a state of different parentage. All of the complexes were also tested for in vitro antibacterial activity against four bacterial strains and for anti-inflammatory activity by measuring lipoxygenase inhibition activity.

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Article information

DOI: https://doi.org/10.1039/C4NJ02203C
Article type: Paper
Submitted: 01 Dec 2014
Accepted: 31 Mar 2015
First published: 08 Apr 2015

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New J. Chem., 2015,39, 4830-4844

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The structural and electronic impact on the photophysical and biological properties of a series of Cu^I and Ag^I complexes with triphenylphosphine and pyrimidine-type thiones

P. A. Papanikolaou, A. G. Papadopoulos, E. G. Andreadou, A. Hatzidimitriou, P. J. Cox, A. A. Pantazaki and P. Aslanidis, New J. Chem., 2015, 39, 4830 DOI: 10.1039/C4NJ02203C

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