Correction: Discovery of fluoroquinolone derivatives as potent, selective inhibitors of PI3Kγ

Abstract

Correction for ‘Discovery of fluoroquinolone derivatives as potent, selective inhibitors of PI3Kγ’ by Shao Sha et al., Med. Chem. Commun., 2015, DOI: 10.1039/c5md00364d.

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The authors regret errors in Fig. 2 and Table 2 of their paper. The structure shown in Fig. 2 should show N1 between C14 and C15 and Table 2 should show R/R′ as 6-MeO for compounds D1 and C1. The corrected figure and table are shown below.

Fig. 2 Molecular structure of compound D1 with atomic numbering scheme.

Table 2 Enzyme activities (IC₅₀, nM) of synthesized compounds against human PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ kinases, respectively

Compound	R/R′	PI3Kγ	PI3Kα	PI3Kβ	PI3Kδ
D1	6-MeO	279	>1000	>1000	>1000
D2	2-Cl	259	>1000	>1000	>1000
C1	6-MeO	285	>1000	>1000	>1000
C2	2-Cl	265	>1000	>1000	>1000
A1	5-Cl	174	963	>1000	553
A2	4-MeO	89	642	>1000	348
A3	3,5-NO2	56	356	>1000	271
A4	5-Br	169	894	>1000	674
A5	5-NO2	185	591	>1000	722
B1	5-Cl	98	712	>1000	311
B2	6-Me	173	914	>1000	683
B3	5-Br	111	695	>1000	474
B4	5-MeO	112	698	>1000	489
CAL-101		92	825	579	3

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The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.

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