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DOI: 10.1039/C5MD90031J (Correction) Med. Chem. Commun., 2015, 6, 1573-1574

Correction: Discovery, synthesis and structure–activity analysis of symmetrical 2,7-disubstituted fluorenones as urea transporter inhibitors

Sujin Lee a, Cristina Esteva-Font a, Puay-Wah Phuan a, Marc O. Anderson b and A. S. Verkman *a
aDepartments of Medicine and Physiology, University of California, San Francisco, CA 94143-0521, USA. E-mail: Alan.Verkman@ucsf.edu
bDepartment of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132-4136, USA

Received 24th June 2015 , Accepted 24th June 2015

First published on 6th July 2015

Abstract

Correction for ‘Discovery, synthesis and structure–activity analysis of symmetrical 2,7-disubstituted fluorenones as urea transporter inhibitors’ by Sujin Lee et al., Med. Chem. Commun., 2015, DOI: 10.1039/c5md00198f.

The authors regret that Scheme 2 and Table 1 contained errors. In Scheme 2 the R group for compound 14 should be N3 instead of CH2N3. In Table 1 compound 17 should be shown as CNOH instead of CNHOH.

The corrected versions of Scheme 2 and Table 1 are shown below.


image file: c5md90031j-s1.tif
Scheme 2
Table 1
Structure Functional group UT-A1 IC50 (μM) UT-B IC50 (μM)
image file: c5md90031j-u1.tif 1 >50 >50
image file: c5md90031j-u2.tif R
2 H >50 >50
3 COCH3 1 1.5
4 COCH2CH3 15 5
5 COCH(CH3)2 18 50
6 CO(CH2)2CH3 >50 >50
7 COCF3 10 7.5
8 CONH2 2 1.2
9 SO2CH3 1.5 2.5
10 SO2(CH2)3 >50 >50
11 COCH2Br 30 10
12 COCH2OH 20 25
13 COCH2O(CH2)2OMe >50 50
14 COCH2N3 20 30
15 COCH2OBn >50 >50
16 CO(CH)2CO2H 30 >50
image file: c5md90031j-u3.tif X
17 CNOH 12 25
18 CHOH >50 20
20 SO2 15 2
image file: c5md90031j-u4.tif R
21 H >50 >50
22 COCH3 18 20
23 COCH2OBn >50 >50
24 SO2CH3 >50 30

The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.

This journal is © The Royal Society of Chemistry 2015