Issue 3, 2015
From the journal:

MedChemComm

Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents†

Alexandra Manos-Turvey,a   Emma E. Watson,a   Melissa L. Sykes,b   Amy J. Jones,b   Jonathan B. Baell,c   Marcel Kaiser,de   Vicky M. Averyb  and  Richard J. Payne*a  

* Corresponding authors

a School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia
E-mail: richard.payne@sydney.edu.au
Fax: +61 2 9351 3329
Tel: +61 2 93515877

b Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia

c Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia

d Swiss Tropical and Public Health Institute, Basel, Switzerland

e University of Basel, Basel, Switzerland

Abstract

The synthesis and anti-trypanosomal activity of a compound library based on a phenoxymethylbenzamide hit discovered in a high throughput screen is described. Several of the analogues exhibited potent activity against Trypanosoma brucei rhodesiense, a human infective strain of the trypanosome parasite, that serve as lead compounds for further optimisation.

Graphical abstract: Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4MD00406J
Article type
Concise Article
Submitted
13 Sep 2014
Accepted
07 Oct 2014
First published
08 Oct 2014

Med. Chem. Commun., 2015,6, 403-406

Permissions

Request permissions

Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

A. Manos-Turvey, E. E. Watson, M. L. Sykes, A. J. Jones, J. B. Baell, M. Kaiser, V. M. Avery and R. J. Payne, Med. Chem. Commun., 2015, 6, 403 DOI: 10.1039/C4MD00406J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements