Chuyuan Lin, Lu Chen, Huaping Lin, Yibiao Li, Chengshuo Shen and Min Zhang
Org. Chem. Front., 2022,9, 2944-2948
DOI:
10.1039/D2QO00074A,
Research Article
By employing a compatible system of selectfluor and NaCl, we herein report a new and practical approach for direct access to aryl α,α-chlorofluoro arylketones in aqueous trifluoroethanol via mild electrophilic heterohalogenation of arylalkynes, featuring metal-free conditions, readily available feedstocks, and good functional group tolerance. The present work offers a raw material basis for further preparation of fluorinated organic molecules.
