Issue 82, 2015
From the journal:

Chemical Communications

Electrochemical aptamer scaffold biosensors for detection of botulism and ricin toxins†

Lisa Fetter,‡a   Jonathan Richards,‡a   Jessica Daniel,a   Laura Roon,a   Teisha J. Rowlandb  and  Andrew J. Bonham*a  

* Corresponding authors

a Department of Chemistry, Metropolitan State University of Denver, Denver, CO 80204, USA
E-mail: abonham@msudenver.edu

b Cardiovascular Institute and Adult Medical Genetics Program, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045, USA

Abstract

Protein toxins present considerable health risks, but detection often requires laborious analysis. Here, we developed electrochemical aptamer biosensors for ricin and botulinum neurotoxins, which display robust and specific signal at nanomolar concentrations and function in dilute serum. These biosensors may aid future efforts for the rapid diagnosis of toxins.

Graphical abstract: Electrochemical aptamer scaffold biosensors for detection of botulism and ricin toxins

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Article information

DOI
https://doi.org/10.1039/C5CC05933J
Article type
Communication
Submitted
16 Jul 2015
Accepted
21 Aug 2015
First published
21 Aug 2015

Chem. Commun., 2015,51, 15137-15140

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Electrochemical aptamer scaffold biosensors for detection of botulism and ricin toxins

L. Fetter, J. Richards, J. Daniel, L. Roon, T. J. Rowland and A. J. Bonham, Chem. Commun., 2015, 51, 15137 DOI: 10.1039/C5CC05933J

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