Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(iv)–acetamidato complex

Abstract

We describe herein a novel Pt(IV)–acetamidato complex as a result of the one-pot reaction between cisplatin and the highly reactive peroxyacetimidic acid generated in situ. This is the first example of a Pt(IV) complex containing a N-donor ligand coordinated during the Pt(II) → Pt(IV) oxidation step. Remarkably, the Pt(IV)-amidato compound is highly soluble and stable in water; it represents an interesting building block for the further development of Pt(IV) antitumor prodrugs.