Issue 12, 2015

Iodine-mediated synthesis of indazolo-quinazolinones via a multi-component reaction

Abstract

We report an expeditious synthesis of selected indazolo-quninazolinone derivatives via an iodine-mediated multi-component reaction (MCR). The MCR involved an in situ generation of the 1H-indazol-3-amine derivative in ethanol followed by its reaction with the diketone and aryl aldehyde in acetonitrile. A number of compounds have been synthesized using this methodology in good yields.

Graphical abstract: Iodine-mediated synthesis of indazolo-quinazolinones via a multi-component reaction

Supplementary files

Article information

Article type
Paper
Submitted
04 Nov 2014
Accepted
16 Dec 2014
First published
17 Dec 2014

RSC Adv., 2015,5, 8640-8646

Author version available

Iodine-mediated synthesis of indazolo-quinazolinones via a multi-component reaction

J. Palaniraja and S. M. Roopan, RSC Adv., 2015, 5, 8640 DOI: 10.1039/C4RA13779E

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