Metal-free synthesis of substituted pyridines from aldehydes and NH4OAc under air

Rulong Yan; Xiaoqiang Zhou; Ming Li; Xiaoni Li; Xing Kang; Xingxing Liu; Xing Huo; Guosheng Huang

doi:10.1039/C4RA10880A

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Metal-free synthesis of substituted pyridines from aldehydes and NH₄OAc under air†

Rulong Yan,*^a Xiaoqiang Zhou,

^a Ming Li,^b Xiaoni Li,^a Xing Kang,^a Xingxing Liu,^a Xing Huo^a and Guosheng Huang*^a

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* Corresponding authors

^a State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Department of Chemistry, Lanzhou University, Lanzhou, P. R. China
E-mail: yanrl@lzu.edu.cn, hgs@lzu.edu.cn
Fax: +86 931 8912596
Tel: +86 931 8912586

^b Jinchuan Group Co., Ltd., Jinchuan, P. R. China

Abstract

A metal-free and efficient method for the synthesis of substituted pyridines with aldehydes and NH₄OAc under mild conditions using air as the oxidant was developed. This oxidative cyclization process involves direct C–H bond functionalization, C–C/C–N bond formation and C–C bond cleavage.

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Article information

DOI: https://doi.org/10.1039/C4RA10880A
Article type: Communication
Submitted: 12 Jun 2014
Accepted: 30 Sep 2014
First published: 01 Oct 2014

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RSC Adv., 2014,4, 50369-50372

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Metal-free synthesis of substituted pyridines from aldehydes and NH₄OAc under air

R. Yan, X. Zhou, M. Li, X. Li, X. Kang, X. Liu, X. Huo and G. Huang, RSC Adv., 2014, 4, 50369 DOI: 10.1039/C4RA10880A

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