A highly enantioselective Friedel–Crafts reaction of activated phenols with isatin derivatives has been developed employing Cinchona-derived thiourea as an organocatalyst. A variety of biologically important 3-aryl-3-hydroxy-2-oxindoles have been synthesized using phenols in good to excellent yield with good enantioselectivity (up to 92% ee).
J. Kaur, A. Kumar and S. S. Chimni, RSC Adv., 2014, 4, 62367 DOI: 10.1039/C4RA09805F
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