Nuclease activity and anti-proliferative effect on human cancerous cells of a newly synthesized and characterized mononuclear copper(II) complex [CuII(L)(fu)2] [L = 2-(2-pyridyl)benzimidazole, fu = furoate]

Sunit Kumar Mal; Merry Mitra; Gurpreet Kaur; V. M. Manikandamathavan; Manikantan Syamala Kiran; Angshuman Roy Choudhury; Balachandran Unni Nair; Rajarshi Ghosh

doi:10.1039/C4RA09448D

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Nuclease activity and anti-proliferative effect on human cancerous cells of a newly synthesized and characterized mononuclear copper(ii) complex [Cu^II(L)(fu)₂] [L = 2-(2-pyridyl)benzimidazole, fu = furoate]†

Sunit Kumar Mal,^a Merry Mitra,^a Gurpreet Kaur,^b V. M. Manikandamathavan,^c Manikantan Syamala Kiran,^d Angshuman Roy Choudhury,^b Balachandran Unni Nair*^c and Rajarshi Ghosh*^a

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* Corresponding authors

^a Department of Chemistry, The University of Burdwan, Burdwan 713 104, India
E-mail: rajarshi_chem@yahoo.co.in
Fax: +91-342-2530452
Tel: +91 342 2533913 ext. 424

^b Department of Chemical Sciences, Indian Institute of Science Education & Research, Mohali, Sector 81, S.A.S. Nagar, Knowledge City, Manauli PO, Mohali 140 306, India

^c Chemical Laboratory, CSIR-Central Leather Research Institute, Adayar, Chennai 600 020, India
E-mail: bunair@clri.res.in

^d Bio-Materials Laboratory, CSIR-Central Leather Research Institute, Adayar, Chennai 600 020, India

Abstract

A mononuclear copper(II) complex [Cu^II(L)(fu)₂] (1) [L = 2-(2-pyridyl)benzimidazole, fu = furoate] has been synthesized and characterized by X-ray crystallography. Structural analysis reveals that 1 adopts a distorted square pyramidal geometry with CuN₂O₃ chromophore. Spectrophotometric and hydrodynamic investigations suggest that the complex binds with DNA in an intercalative mode with a binding constant of (3.19 ± 0.32) × 10⁴ M⁻¹. 1 induces oxidative cleavage of the supercoiled DNA to its nicked circular as well as linear forms. 1 is also proved to be an anti-cancer agent on human keratinocyte cells.

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DOI: https://doi.org/10.1039/C4RA09448D
Article type: Paper
Submitted: 04 Sep 2014
Accepted: 06 Nov 2014
First published: 14 Nov 2014

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RSC Adv., 2014,4, 61337-61342

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Nuclease activity and anti-proliferative effect on human cancerous cells of a newly synthesized and characterized mononuclear copper(II) complex [Cu^II(L)(fu)₂] [L = 2-(2-pyridyl)benzimidazole, fu = furoate]

S. K. Mal, M. Mitra, G. Kaur, V. M. Manikandamathavan, M. S. Kiran, A. R. Choudhury, B. U. Nair and R. Ghosh, RSC Adv., 2014, 4, 61337 DOI: 10.1039/C4RA09448D

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