Self-assembled amphoterecin B loaded into a self-assembled cardanol derivative as a soft green carrier for delivery and enhanced antifungal activity

Abstract

Self-assembly strategies are used for soft green carrier (SGC) preparation from cardanol after modification with benzenediazonium functional moieties (PHPDB). A spherical core-shell like self-assembled structure of Amphotericin B (AmpB) was loaded into PHPDB and released in aqueous medium. AmpB and PHPDB show ergosterol and chitin binding affinity, respectively, and sustain enhanced activity with proficient biofilm eradication.