DOI:
10.1039/C4RA07065H
(Paper)
RSC Adv., 2014,
4, 39359-39364
A facile acidic choline chloride–p-TSA DES-catalysed dehydration of fructose to 5-hydroxymethylfurfural
Received
13th July 2014
, Accepted 8th August 2014
First published on 11th August 2014
Abstract
The conversion of lignocellulosic biomass to biofuel precursors has recently been a focus of intensive research due to the essential role of biofuels as transport fuels in the future. Specifically, the conversion of fructose to 5-hydroxymethylfurfural (5HMF) has gained momentum, as 5HMF is a versatile bio-based platform molecule that leads to a plethora of high-value chemicals and biofuel molecules, such as DMF. Herein, we report the use of an environmentally friendly, Brønsted acidic, deep eutectic mixture consisting of choline chloride (ChCl) and p-TSA for the dehydration of fructose to 5HMF. Unlike previous systems, the use of ChCl–p-TSA plays a dual role, as both a hydrogen bond donor (HBD) and a catalyst for the dehydration reaction, thus obviating the addition of an external acid. The reaction was examined and optimised in a batch system, where it was found that fructose was readily dehydrated to 5HMF. The best reaction conditions, with the highest 5HMF yield of 90.7%, were obtained at a temperature of 80 °C using a DES molar mixing ratio of 1
:
1 ChCl
:
p-TSA and feed ratio of 2.5%, and with a reaction time of one hour.
1. Introduction
The depletion of petroleum resources, subsequent changes in world economies, the increase in greenhouse gas emissions, and the associated climate change are a few of the issues that reveal the urgent need for renewable and green energy resources.1 Lignocellulosic biomass is predominant among the renewable sources for future bioenergy. It is low-cost, abundant, and does not compete with food resources. Fructose derived from lignocellulosic biomass has been found to be among the best carbohydrate sources of furans.2
One of the most important block intermediate materials obtained from the direct dehydration of fructose is 5HMF. The fructose dehydration reaction mechanism and its possible side reactions are illustrated in Scheme 1. 5HMF is regarded as an important block material, as it has many derivatives that can be used as biofuel precursors and useful chemicals.4–6 The main derivatives of 5HMF are illustrated in Scheme 2.
 |
| Scheme 1 Schematic diagram of acid-catalyzed fructose dehydration reaction and the possible subreaction pathways.3 | |
 |
| Scheme 2 Possible derivatives of 5HMF.7 | |
5HMF was first produced by Dull et al. in the 19th century by pressurised heating of inulin in oxalic acid.8 Subsequently, different acid catalysis systems consisting of mineral acids,9,10 solid acids,11,12 and metallic acids10 were studied to improve the yields of 5HMF in aqueous medium by catalytic fructose dehydration reactions. The common drawback of these systems was the requirement for relatively high reaction temperatures, which lead to low 5HMF yields because of the rehydration of the product 5HMF.4,13,14
To overcome the drawbacks of aqueous systems, different organic solvents, such as dimethyl sulfoxide (DMSO), dimethylformamide (DMF), acetic acid and methanol have been investigated. Despite a higher yield of 5HMF obtained with these solvents, some limitations were encountered. The poor solubility of sugars in many organic solvents, the difficult separation of 5HMF in high boiling point organic solvents and the poor extraction efficiency of low boiling point organic solvents pose a barrier to utilizing these systems. Similar challenges are faced with biphasic systems, such as methyl isobutyl ketone (MIBK) and n-butanol (BuOH) in water to extract the produced 5HMF.7
Recently, the use of ionic liquids (ILs) in fructose dehydration to 5HMF showed increased promise because of their unique properties, namely, low vapour pressure, non-flammability, high chemical and thermal stability, and ability to adjust solvent power.15
Lansalot obtained 5HMF yield of 68% when 5 wt% of fructose was solubilised in dimethyl sulfoxide (DMSO) and catalysed by p-TSA in 1-butyl-3-methylimidazolium as ionic liquid solvent for 32 h.16
Quan Cao studied the fructose dehydration to 5HMF in different imidazolium ionic liquids. He concluded that the acidic C-2 hydrogen of imidazolium cations acts as catalyst for the fructose dehydration reaction, even when no catalyst was used.17
Although the use of ionic liquids highly improved the 5HMF yields obtained from fructose dehydration, the elevated cost and unclear environmental effects of the conventional ionic liquids still pose a challenge for establishing a robust production process of 5HMF using the I system. Therefore, research attention has turned to room temperature ILs. Those liquids contain organic salts with melting point below 100 °C, namely choline chloride-based ILs18 and amino acid based ILs.19
In this matter, Suqin and others conducted a fructose dehydration reaction to 5HMF using a biphasic system comprised of renewable ionic liquid and ethyl acetate as extraction solvent.20
The latest form of these solvents are the deep eutectic solvents (DES), developed by Abbott.21 DES are mixtures made of different ammonium salts, such as choline chloride, and different spaces of hydrogen bond donors, namely amides, amines, alcohols and different acids.22 Briefly, the chemistry concept of these mixtures is an ionic interaction between the hydrogen bond donor (HBO) and the salt, which leads to a decrease in both melting and freezing points of the mixture.23,24 In addition to sharing similar properties with normal ionic liquids, DES mixtures retain superior advantages; they have low cost and are biodegradable and easy to prepare. Choline chloride–urea is the most commonly used DES mixture;25 it has been widely used as solvent and co-solvent in many catalytic chemical synthesis applications.26,27
DES have been found to be active catalytic mixtures in biomass hydrolysis.27 Hayyan et al. used a DES mixture of N,N-diethylenethanol ammonium chloride and p-TSA for free fatty acid esterification to biodiesel fuel28 and a mixture of p-toluene sulfonic acid monohydrate (p-TSA) and allyltriphenylphosphonium bromide to produce biodiesel from low-grade palm oil.29
Liu reported the synthesis of 5HMF from concentrated solutions of fructose by using a DES mixture formed from choline chloride and carbon dioxide; a yield of 62% was obtained.30
In all of the above studies, a range of DES has previously been utilised for the hydrolysis of fructose to 5HMF requiring the addition of an acid catalyst, which is generally undesirable from a processing viewpoint.
This work investigates an acidic DES derived from choline chloride (ChCl) and p-toluene sulfonic acid monohydrate (p-TSA) to dehydrate fructose to 5HMF, which obviates the addition of an acid catalyst. The selected DES was found to be highly efficient, and 90.7% yield of 5HMF was obtained. It was produced from cheap and renewable materials, rendering it environmentally friendly. The use of p-TSA as both HBO and catalyst would reduce the processing cost.
2. Results and discussion
2.1 The effect of feed ratio
As illustrated in section 5, the feed mass ratio was calculated as the percentage of fructose in the reaction mixture at the start. As shown in Fig. 1, the 5HMF yield decreases with increasing fructose mass ratio. This may be attributed to 5HMF being rehydrated by the presence of water produced from the dehydration reaction of fructose. The highest yield obtained was 90.7% at a mass ratio of 2.5%, after which the yield sharply decreased to 52.3% at a feed mass ratio of 10%. As the feed ratio increased from 20% to 100%, the 5HMF yield decreased gradually. The lowest yield was 20.5% at a feed ratio of 100%. This can be attributed to the fact that increasing the initial fructose concentration could result in subsequently high 5HMF concentration, which then leads to the occurrence of unwanted side reactions.31 These reactions are expected to produce insoluble humins and/or soluble polymers,32 which lead to a decrease in 5HMF yield. The change of the sample colour to a darker brown by increasing the fructose ratio is another sign for the production of these undesirable by-products in the dehydration reaction. Self-polymerization of 5HMF and cross-polymerization between fructose and 5HMF could produce polymers in fructose dehydration reactions.33 It was mentioned that the increase of initial fructose concentration would encourage the occurrence of polymerization reactions, which would decrease the 5HMF selectivity7 as illustrated in Fig. 2. The highest yield was obtained at a feed ratio of 2.5%. Upon analysis 2.5% feed ratio gave unstable results, therefore 5% feed ratio was selected for subsequent experiments.
 |
| Fig. 1 Effect of feed ratio on 5HMF yield and fructose conversion. | |
 |
| Fig. 2 Effect of feed ratio on 5HMF selectivity. | |
2.2 The effect of reaction time
The effect of reaction time on the fructose dehydration reaction was investigated in 10 minute intervals up to 120 minutes of reaction time, as shown in Fig. 3.
 |
| Fig. 3 The effect of reaction time on HMF yield, HMF selectivity and fructose conversion. | |
Fructose conversion was mostly steady for the entire reaction timescale. The yield and selectivity of 5HMF showed almost similar trends. 5HMF yield of 57.5% was obtained at 10 minutes reaction time, then it increased to 63.7% at 30 minutes. The selectivity showed a slight increase from 65.5% at 10 minutes to 68.3% at 30 minutes. Over the course of 40 to 120 minutes of reaction time, the yield and selectivity did not show a definite trend, except for wavering around 70% yield ±10%. This could only be attributed to the possible rehydration of 5HMF and the formation of side products by degradation.34 For this reason, a reaction time of 1 h was selected as the optimum time.
2.3 The effect of reaction temperature
The effect of reaction temperature on the dehydration reactions was investigated in a temperature range of 50 °C to 110 °C, as shown in Fig. 4. The recorded temperature was the oil bath temperature, and not the temperature inside the reaction beaker.
 |
| Fig. 4 Effect of reaction temperature. | |
A DES mixture of 1
:
1 ChCl to p-TSA was used. Fructose conversion increased with temperature from 77.1% at 50 °C to 99% at 110 °C, keeping a generally high conversion over the whole temperature range.
On the other hand, 5HMF yield was almost steady at 65.0%, 65.2% and 63.8%, when the reactions were conducted at 50 °C, 60 °C and 70 °C, respectively. A highest yield of 70.6% was obtained at 80 °C, after which the yield started to decrease with increasing reaction temperature. The lowest yield recorded was 50.6% at 110 °C, where the sample colour was very dark. This might be due to thermal degradation to humins. Based on these results, 80 °C was selected as the best reaction temperature.
As for 5HMF selectivity, Fig. 4 shows a general decrease with increasing reaction temperature, while remaining generally high. The highest 5HMF selectivity was 84.3% at 50 °C, and the lowest selectivity was 51.1% at 110 °C. On the other hand, the highest fructose conversion was 99% at 110 °C, while the lowest was 77.1% at 50 °C.
2.4 The effect of DES mixing molar ratio
Deep eutectic solvent (DES) molar mixing ratio had great effect on the 5HMF yield and selectivity in fructose dehydration reactions, as DES plays a dual role as solvent and catalyst. In this work, different DES mixing molar ratios were investigated as shown in Table 1, at constant feed ratio of 5 wt%, in order to have a clear assessment of the effect of the DES mixing ratio.
Table 1 Parameters studied and their ranges
Variable |
Range |
Temperature °C |
50, 60, 70, 80, 90, 100, and 110 |
Reaction time (minute) |
10–120 |
Feed mass ratio (%) |
2.5–100 |
DES mixing molar ratio (%) ChCl : p-TSA |
1 : 0.5, 1 : 1, 1 : 1.5 and 1 : 2 |
As shown in Fig. 5, changing the ratio from 1
:
0.5% to 1
:
1.5% had a positive effect on 5HMF yield and selectivity. The yield increased from 53% at a molar mixing ratio of 1
:
0.5 to 70% at a 1
:
1 molar mixing ratio, reaching a value of 78.3% at a molar mixing ratio of 1
:
1.5. On the other hand, when the mixing molar ratio of DES increased to 1
:
2, a severe decrease in the 5HMF yield, down to 29.2%, was observed.
 |
| Fig. 5 Effect of DES mixing molar ratio. | |
A similar effect of the DES ratio on yield was seen on 5HMF selectivity. The lowest selectivity of 33.9% was obtained at a 1
:
2 molar mixing ratio, while the highest selectivity of 92.6% was obtained at a 1
:
1.5 molar mixing ratio.
The effect of DES molar mixing ratio on fructose conversion was not prominent. It was steady around the range of 84.5% to 93.3% at molar mixing ratio of 1
:
1.5 and 1
:
1, respectively.
Other experiments were conducted, where 5HMF yield was investigated as function of DES ratio, keeping the feed ratio constant at 2.5 wt%. Fig. 6 shows that a maximum 5HMF yield of 90.7% was obtained at 1
:
1 DES molar mixing ratio. It decreased to 58.4% when the DES molar mixing ratio was increased to 1
:
1.5. This further proves that the 2.5 wt% feed ratio, 1
:
1 DES molar mixing ratio and 80 °C at 1 hour of reaction time are the best operating conditions for the investigated system.
 |
| Fig. 6 5HMF yield % vs. DES mixing ratio at a feed ratio of 2.5%. | |
3. Experimental
3.1 Materials
Fructose (99%), 5-hydroxymethylfurfural (99%) and p-toluene sulfonic acid monohydrate (p-TSA) (98.5%) were ordered from Sigma Aldrich; choline chloride (99%) was ordered from Acros; and calcium hydroxide analytical reagent was ordered from Riedel-DeHaen. All materials were used with no further purification.
3.2 Preparation of deep eutectic solvent (DES)
Choline chloride and p-toluene sulfonic acid (p-TSA) were dried under vacuum at 60 °C for 2 h prior to use, and then mixed together in different molar ratios at 80 °C, using an oil bath and magnetic stirrer at 300 rpm. After half an hour, a colourless, thick, homogenous liquid mixture was obtained. The preparation was carried out in a fume hood. A similar procedure was used by Hayyan to prepare DES of p-TSA and N,N-diethanol ammonium chloride to produce biodiesel from fatty acid.28
3.3 Fructose dehydration reaction in DES procedure
All the fructose dehydration reactions were carried out in a 100 mL glass beaker clamped in an oil bath, using a magnetic stirrer at 300 rpm. Afterwards, the required amount of fructose was added and stirred at 300 rpm for 1 hour at 80 °C. At the end of the reaction, the thick dark brown reaction mixture was cooled down to room temperature and then dissolved in 10 mL of HPLC-grade water. Next, the initial pH was measured by using a pH meter and then adjusted to neutral by using 2 M of calcium hydroxide solution (Ca(OH)2). The entire sample was poured into a 100 mL calibration flask and then diluted by HPLC-grade water to 100 mL. 2 mL of the sample was passed through a syringe filter, bottled in HPLC vials, and then shaken for HPLC analysis.
4. HPLC analysis
The reactant fructose and product 5HMF were analysed by an HPLC 1100 Agilent series equipped with a refractive index detector and Rezex RCM-monosaccharide column (300 × 7.8 mm), ordered from Phenomenex. The analytical method used 100% HPLC-grade water from VWR as mobile phase, at flow rate of 0.5 mL min−1, column oven temperature of 75 °C, injection volume of 20 μL and total time of 40 minutes.
5. Variables and equations
The 5HMF yield, selectivity and fructose conversion were calculated as follows:
The experimental conditions and variable ranges investigated in this work are listed in Table 1.
6. Conclusion
The deep eutectic solvent mixture of ChCl–p-TSA was found to be a highly promising catalytic solvent mixture for the reaction of fructose dehydration to 5HMF, giving a high yield and selectivity. The dehydration process using such mixture was found to be efficient, as the DES mixture comprised renewable, non-toxic and cheap materials. The process did not require severe reaction conditions, as 80 °C was found to be the best reaction temperature. There was no need to use an external catalyst, as the p-TSA serves as both hydrogen bond donor (HBD) and acid catalyst for the dehydration reaction. The DES mixture was easy to prepare and had no contamination effect, as it is not reactive. The best yield obtained was 90.7% at a feed ratio of 2.5 wt%, DES mixing molar ratio of 1
:
1, 80 °C temperature and 1 h reaction time. Further investigations are required for an efficient separation process for the final product 5HMF. Also, further analysis is required to identify the by-products obtained from the concurrent side reactions.
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